Side Effects of Natural Progestesterone Cream used for Migraine Headaches

Side Effects of Bioidentical Natural Progesterone Cream for Migraine Headaches

Worse NOT Better

Side Effects of Natural Progesterone can paradoxically make the migraine headaches temporarily worse (30-40% of patients) if they do not cut out xenoestrogens. If the patient cuts out xenoestrogens diligently, then the success rate for progesterone cream stopping the migraine is above 90%. The key to getting rid of bad side effects of bioidentical progesterone is to get rid of xenoestrogens in the environment.

Whatever is put on the skin is 10 times as potent compared to what is put in the mouth. Whatever is put on the skin goes directly into the body. However, whatever is taken orally is 90% prefiltered by the liver. For instance, a 20 mg topical dose of progesterone is equivalent to a 200 mg oral dose of progesterone. Thus, laundry detergent, soap, shampoo, cosmetics and deodorant is more critical to change than eating organic vs non-organic food.

The reason why it is so important to cut out xenoestrogens, is that if you do not cut them out then you will get an "too much estrogen" temporary response when you take progesterone (only 30-40% of patients). For migraine sufferers, this means the headache gets worse. If you read the progesterone cream forums, you will find that some women love progesterone. The bloating goes away. The migraine headache goes away. The breast tenderness goes away. Then, there are some women that hate progesterone. The bloating gets worse. The headache gets worse. The breast tenderness gets worse. The migraine gets worse.

What is going on?

The women who temporarily get worse migraine headaches on progesterone cream have large amounts of xenoestrogens in their environment. The women that say progesterone doesn't work send back their progesterone cream bottles and typically their bottles are fragrant beyond belief. They are the ones using all sorts of synthetic chemicals, frgrances natural and artificial, and beauty products. Many of these products just happen to contain chemicals that mimic estrogen. The chemicals were not intended to be estrogen. These chemicals just happen to fool the body into thinking it is estrogen. These unintentional estrogens masqueraders were put into the personal products as preservatives, fragrances, or calming herbs. The designers of the products did not consider the hormone disruptive effects of these chemicals.

Why is it like this?

Why is it that for some women (60-70%) progesterone cream works great? While for some women (30-40%) progesterone cream makes them sicker and their migraines worse?

If you have a large load of environmental estrogens (xenoestrogens or chemical estrogens), then the body adapts by becoming less sensitive to estrogen. The technical term for this is "down regulation".

It is sort of like going to a rock concert. Initially, when you go to a rock concert it sounds loud. Then after about one half hour, it is not so loud any more. This is because your ears "down regulate" to the loud noise and the loud noise seems less loud.

When you take progesterone cream all of a sudden, the rock music seems loud again. The initial reaction is, "Damn, this progesterone cream is make the rock concert loud again! This progesterone is junk! The progesterone cream is making the rock concert loud!"

Did the noise from the rock concert really become louder? No, the decibel level of the rock concert is unchanged. It is your sensitivity to the rock concert that has changed. Your sensitivity was initially normal. The music was loud. Then you had down regulation. The rock concert became more bearable after one half hour. Then, you took progesterone cream and the rock concert became loud again.

This is the same analogy to estrogen load. Most women in America have a high load of estrogen in the form of chemicals that mimic estrogen. They down regulate to the environmental estrogen. They become less sensitive to the estrogen. When these women take bioidentical progesterone cream, they the estrogen becomes "loud again". They have more breast tenderness and more bloating and more migraine headaches.

What is the long term solution?

The long term solution is to get rid of the loud rock concert! The long term solution is to get rid of the environmental estrogens. Now the question is what are these environmental estrogens? What is important and what is not. Here is a website that gives out a LIST OF XENOESTROGENS with its products free.

I Did Not Have Even a Hint of a Headache

Dr. Eckhart,

Just wanted to let you know that I am no longer having headaches with my periods as I had reported to you last. I did purchase a bottle of butterbur as you recommended. I'm happy to say that I did not have to use it. I have had 3 periods over the past 3 months (much more regular than I've been in quite awhile, by the way) and I did not have even a hint of a headache with any of them!

I have moved from the desert in eastern Washington to the west side of the state on the Long Beach peninsula. The reason for my move was because of my love to be near the Pacific Ocean. However, I am hoping that the environment will be healthier in regard to xenoestrogen exposure since I am no longer surrounded by farming and since there is an almost constant breeze of fresh ocean air!

Without a doubt, I will remain a faithful user of Progestelle. Thank you again for all your help.

God bless,

Claudia M., Nahcotta, WA

Allergies - Rash, Insomnia

About one out of 400 patients have a rash or insomnia when they take progesterone cream. This is an allergy to the cream base that the progesterone is in and not to the progesterone itself. The allergy may last for several days to 2 weeks. The allergy is to the cream base and not the progesterone. So another progesterone cream may work because the cream base is different. Taking a teaspoon of baking soda in a glass of water several times per day as well as Benadryl may help with the allergy. I like to get pharmaceutical grade baking soda (sodium bicarbonate) instead of using the one in the grocery store. Pure baking soda should be salty, not bitter. Bitter baking soda may indicate the presence of contaminants. out of 10,000 patients, I have found about 2-4 patients that may have been allergic to progesterone. This is rare, but possible. Beer, MD documented patients that were allergic to progesterone.

Here is a website that sells progesterone dissolved in vegetable oil. They have several oils available. Should you be allergic to one oil, you can switch to another oil. The progesterone is dissolved in the oil. A cream has water and oil together. The water is for show. The progesterone is in the oil. More is less. The less you have in the formulation, the less you have to be allergic to.

Progesterone Cream Makes You Sleepy

Natural Progesterone cream will make you sleepy. So for some patients that have insomnia, they like to use progesterone right before they go to sleep. Progesterone induces a nice sleep. Oral progesterone make you VERY sleepy. Again a 20 mg/day topical dose of progesterone is equivalent to a 200 mg/day oral dose. The liver metabolizes 90% of the oral dose of progesterone. No one knows what those 90% metabolites do, but I do know that it makes you very sleepy.

I had one patient that was given 400 mg/day oral dose of progesterone. She took the 400 mg of oral progesterone and drove to Wal-Mart. She had to call her husband to come pick her up because she was too sleepy to drive back home.

Shortness of Breath and Heart Palpitations - Diabetes Type II helped

Some patients report that they have had shortness of breath and transient heart palpitations. This seems to be linked to the anti insulin resistance effect of progesterone. Too much estrogen contributes to insulin resistance. Diabetes type II is made worse by Estrogen Dominance or too much estrogen. Progesterone opposes estrogen. Progesterone will lower sugar levels in the blood. Many times Diabetes Type II patients will get better using topical progesterone. The diabetes type II patient will have less of a need for insulin and drugs. Many times the requirement for these drugs becomes less.

Because of the slight lowering effect of sugar in the blood of progesterone when you first take progesterone, you may have some heart palpitations and or shortness of breath. Simply wash off the progesterone and eat some carbohydrates. The next day use less progesterone.

Sometimes eating some carbohydrate - a mouthful of bananas or cereal is enough to stop the heart palpitations and shortness of breath.

It Has Really Helped!


I wanted to tell you how happy I am with Progestelle. I have been using it now for just over 2 months and I feel great. I originally started using it to lessen my migraine headaches and it has really helped. If I get one, it is only one, and mild and goes away in about an hour or so. I'm hoping that they disappear completely as time goes on. Also, my periods are very regular which hasn't been the case for the past 2 years. Definitely the oil. No PREMENSTRUAL SYNDROME too!

I also want to tell you how nice it is to have a Dr. who actually responds to your emails and phone calls. You really sound sincere and take the time to explain everything. I've recommended the product to others who I'm sure will experience the same benefits as I have.

Thank you again.

Tish M., Huntington, New York

Irregular periods.

Most of the time progesterone is supposed to normalize your period. However, with the elimination of xenoestrogens and phytoestrogens, and then taking progesterone, and the resensitization of estrogen receptors back to normal there is a push and pull of estrogen and progesterone. Thus, sometimes the period may become irregular.

This is not a problem. Simply eliminate xenoestrogens and phytoestrogens. It may take 1-3 months for them to wash out of the body. Then, take progesterone. Then the cycle normalizes. (A simple application of sunscreen may take 3 months to wash out of the body).

Stopping Ovulation

If you take progesterone cream before ovulation in sufficient amounts (60 mg/day), this will stop ovulation. The ovaries will look at the progesterone levels in the blood and think that you are pregnant. They will stop producing follicles.

This may be used to decrease estradiol levels. Endometriosis and Adenomyosis would get better from the lower estradiol levels in the body.

This effect may also be used to prevent new ovarian cysts from forming as well. An ovarian cyst is simply a follicle that has NOT popped to create a corpus luteum. The follicle just keeps growing and becomes an ovarian cyst.

Natural Progesterone Stops Miscarriage And Premature Delivery

Fertility Medical Doctors frequently use bioidentical progesterone to stop miscarriage. Artificial brand name prescription progestins will create birth defects. Bioidentical progesterone does NOT create birth defects. You should be under the supervision of a health care practitioner to use natural progesterone to prevent miscarriage.

Most of the time 60 mg/day of progesterone split into two doses, one the morning and one at night is sufficient to stop miscarriage. Topical progesterone levels go up and down in about 7 hours. So you usually take it twice per day. But you can also take it three times per day. 15% of all recognized pregnancies end in miscarriage. 80% of miscarriage happens during the first trimester. Topical progesterone cream easily prevents a miscarriage in the first trimester, but can also prevent miscarriage and premature delivery as well.

During the first trimester, the corpus luteum produces progesterone at 20-40 mg/day. Then during the second and third trimesters the placenta produces even more progesterone. During one day of third trimester pregnancy, the body produces 400 mg/day of progesterone.

You can easily take more than 60 mg/day of topical progesterone. Keep in mind that 60 mg/day topically is equivalent to 600 mg/day orally, rectally, or vaginally. If the woman is currently having contractions, you may take 200 mg/day of progesterone to stop the contractions.

The only danger of taking progesterone during pregnancy is that you cannot allow progesterone levels to drop suddenly. Dropping progesterone levels will signal to the body that the pregnancy is over and will create a miscarriage.

So you can go up suddenly on the progesterone level. However, you must come down slowly on the progesterone level usually after the 1st trimester.

There is no danger to take progesterone throughout the entire pregnancy. In fact, progesterone may be used to prevent premature delivery.

For women that are allergic to progesterone, Very allergic, have Hashimoto's Thyroiditis, these women are extremely allergic and may have developed antibodies against progesterone. These women should take progesterone throughout the entire pregnancy. Again, they should not stop taking progesterone suddenly. Stopping progesterone suddenly will create a miscarriage.

Also one out of 400 women do not absorb progesterone well topically. These women can either switch to a different progesterone cream or take progesterone orally. A saliva progesterone test may be used to test if the woman is absorbing progesterone.

Learn more about Natural Bioidentical Progesterone Here.

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